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Article

Sphingosine-1-Phosphate Is a Novel Regulator of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activity.

PloS one - 1 Jan 2015

Malik Firhan A, Meissner Anja, Semenkov Illya, Molinski Steven, Pasyk Stan, Ahmadi Saumel, Bui Hai H, Bear Christine E, Lidington Darcy, Bolz Steffen-Sebastian

Abstract excerpt

The cystic fibrosis transmembrane conductance regulator (CFTR) attenuates sphingosine-1-phosphate (S1P) signaling in resistance arteries and has emerged as a prominent regulator of myogenic vasoconstriction. This investigation demonstrates that S1P inhibits CFTR activity via adenosine monophosphate-activated kinase (AMPK), establishing a potential feedback link. In Baby Hamster Kidney (BHK) cells expressing...

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Identifiers

PMID: 26079370
DOI: 10.1371/journal.pone.0130313
PMCID: PMC4469317

Genes

CFTR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Sphingosine-1-Phosphate Is a Novel Regulator of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activity.PMID 26079370Read ↗

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