Dibasic phosphorylation sites in the R domain of CFTR have stimulatory and inhibitory effects on channel activation.

doi:10.1152/ajpcell.00504.2003

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Dibasic phosphorylation sites in the R domain of CFTR have stimulatory and inhibitory effects on channel activation.

American journal of physiology. Cell physiology - 1 Sept 2004

Vais Horia, Zhang Rugang, Reenstra William W

Abstract excerpt

To better understand the mechanisms by which PKA-dependent phosphorylation regulates CFTR channel activity, we have assayed open probabilities (P(o)), mean open time, and mean closed time for a series of CFTR constructs with mutations at PKA phosphorylation sites in the regulatory (R) domain. Forskolin-stimulated channel activity was recorded in cell-attached and inside-out excised patches from transiently...

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Dibasic phosphorylation sites in the R domain of CFTR have stimulatory and inhibitory effects on channel activation.

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Dibasic phosphorylation sites in the R domain of CFTR have stimulatory and inhibitory effects on channel activation.

Abstract excerpt

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