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Article

Catalytically-active complex of HIV-1 integrase with a viral DNA substrate binds anti-integrase drugs.

Proceedings of the National Academy of Sciences of the United States of America - 19 May 2009

Alian Akram, Griner Sarah L, Chiang Vicki, Tsiang Manuel, Jones Gregg, Birkus Gabriel, Geleziunas Romas, Leavitt Andrew D, Stroud Robert M

Abstract excerpt

HIV-1 integration into the host cell genome is a multistep process catalyzed by the virally-encoded integrase (IN) protein. In view of the difficulty of obtaining a stable DNA-bound IN at high concentration as required for structure determination, we selected IN-DNA complexes that form disulfide linkages between 5'-thiolated DNA and several single mutations to cysteine around the catalytic site of IN. Mild...

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Identifiers

PMID: 19416821
DOI: 10.1073/pnas.0811919106
PMCID: PMC2688900

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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