Article
Structural basis for functional tetramerization of lentiviral integrase.
PLoS pathogens - 1 Jul 2009
Hare Stephen, Di Nunzio Francesca, Labeja Alfred, Wang Jimin, Engelman Alan, Cherepanov Peter
Abstract excerpt
Experimental evidence suggests that a tetramer of integrase (IN) is the protagonist of the concerted strand transfer reaction, whereby both ends of retroviral DNA are inserted into a host cell chromosome. Herein we present two crystal structures containing the N-terminal and the catalytic core domains of maedi-visna virus IN in complex with the IN binding domain of the common lentiviral integration co-factor...
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