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Article

Structural Implications of Genotypic Variations in HIV-1 Integrase From Diverse Subtypes

2 Aug 2018

Abstract excerpt

Human immunodeficiency virus type 1 (HIV-1) integrase (IN) integrates viral DNA into the host genome using its 3'-end processing and strand-transfer activities. Due to the importance of HIV-1 IN, it is targeted by the newest class of approved drugs known as integrase strand transfer inhibitors (INSTIs). INSTIs are efficient in maintaining low viral load; however, as with other approved antivirals, resistance...

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PMID: 30116231
DOI: 10.3389/fmicb.2018.01754

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