Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis.

eLife - 22 Sept 2020

Elliott Jennifer L, Eschbach Jenna E, Koneru Pratibha C, Li Wen, Puray-Chavez Maritza, Townsend Dana, Lawson Dana Q, Engelman Alan N, Kvaratskhelia Mamuka, Kutluay Sebla B

Abstract excerpt

A large number of human immunodeficiency virus 1 (HIV-1) integrase (IN) alterations, referred to as class II substitutions, exhibit pleiotropic effects during virus replication. However, the underlying mechanism for the class II phenotype is not known. Here we demonstrate that all tested class II IN substitutions compromised IN-RNA binding in virions by one of the three distinct mechanisms: (i) markedly reducing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Capsid
Share to Genome, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV Integrase

Share to Protein Multimerization

Share to Ribonucleoproteins

Share to Virion

Share to Virus Integration

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 32960169
DOI: 10.7554/eLife.54311
PMCID: PMC7671690

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis.PMID 32960169Read ↗

Going beyond Integration: The Emerging Role of HIV-1 Integrase in Virion MorphogenesisSemantic proximity Read ↗

Multimodal Functionalities of HIV-1 IntegraseSemantic proximity Read ↗

A Conformational Escape Reaction of HIV-1 against an Allosteric Integrase Inhibitor.Semantic proximity Read ↗

Human immunodeficiency virus type 1 integrase mutants retain in vitro integrase activity yet fail to integrate viral DNA efficiently during infectionSemantic proximity Read ↗

Mutations in the catalytic core or the C-terminus of murine leukemia virus (MLV) integrase disrupt virion infectivity and exert diverse effects on reverse transcription.Semantic proximity Read ↗

Emergence of Compensatory Mutations Reveals the Importance of Electrostatic Interactions between HIV-1 Integrase and Genomic RNA.Semantic proximity Read ↗

Allosteric HIV-1 Integrase Inhibitors Lead to Premature Degradation of the Viral RNA Genome and Integrase in Target CellsSemantic proximity Read ↗

Human Immunodeficiency Virus Type 1 Integrase Protein Promotes Reverse Transcription through Specific Interactions with the Nucleoprotein Reverse Transcription ComplexSemantic proximity Read ↗

Sequential Deletion of the Integrase (Gag-Pol) Carboxyl Terminus Reveals Distinct Phenotypic Classes of Defective HIV-1Semantic proximity Read ↗

Impairment of human immunodeficiency virus type-1 integrase SUMOylation correlates with an early replication defect.Semantic proximity Read ↗

Non-catalytic site HIV-1 integrase inhibitors disrupt core maturation and induce a reverse transcription block in target cells.Semantic proximity Read ↗

The Hunt for HIV-1 Integrase InhibitorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.