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Article

A Conformational Escape Reaction of HIV-1 against an Allosteric Integrase Inhibitor.

Journal of virology - 15 Sept 2020

Nakamura Tomofumi, Nakamura Teruya, Amano Masayuki, Miyakawa Toshikazu, Yamagata Yuriko, Matsuoka Masao, Nakata Hirotomo

Abstract excerpt

HIV-1 often acquires drug-resistant mutations in spite of the benefits of antiretroviral therapy (ART). HIV-1 integrase (IN) is essential for the concerted integration of HIV-1 DNA into the host genome. IN further contributes to HIV-1 RNA binding, which is required for HIV-1 maturation. Non-catalytic-site integrase inhibitors (NCINIs) have been developed as allosteric IN inhibitors, which perform anti-HIV-1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32611758
DOI: 10.1128/JVI.00486-20
PMCID: PMC7495394

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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