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Article

Going beyond Integration: The Emerging Role of HIV-1 Integrase in Virion Morphogenesis

9 Sept 2020

Abstract excerpt

The HIV-1 integrase enzyme (IN) plays a critical role in the viral life cycle by integrating the reverse-transcribed viral DNA into the host chromosome. This function of IN has been well studied, and the knowledge gained has informed the design of small molecule inhibitors that now form key components of antiretroviral therapy regimens. Recent discoveries unveiled that IN has an under-studied yet equally vital...

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PMID: 32916894
DOI: 10.3390/v12091005

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