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Article

Efficient Concerted Integration by Recombinant Human Immunodeficiency Virus Type 1 Integrase without Cellular or Viral Cofactors

1 Apr 2002

Abstract excerpt

Replication of retroviruses requires integration of the linear viral DNA genome into the host chromosomes. Integration requires the viral integrase (IN), located in high-molecular-weight nucleoprotein complexes termed preintegration complexes (PIC). The PIC inserts the two viral DNA termini in a concerted manner into chromosomes in vivo as well as exogenous target DNA in vitro. We reconstituted nucleoprotein...

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Identifiers

PMID: 11884535
DOI: 10.1128/jvi.76.7.3105-3113.2002

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Source receipt: pubmed, retrieved 7 Sept 2026.

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