Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Site-directed mutagenesis of HIV-1 integrase demonstrates differential effects on integrase functions in vitro.

The Journal of biological chemistry - 25 Jan 1993

Leavitt A D, Shiue L, Varmus H E

Abstract excerpt

The retroviral integrase (IN) protein is essential for integration of retroviral DNA into the host cell genome. To identify functional domains within the protein and to assess the importance of conserved residues, we performed site-directed mutagenesis of HIV-1 IN and analyzed the mutants in vitro for IN-mediated activities: 3' processing (att site-specific nuclease activity), strand transfer (the joining of att...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Amino Acid Sequence
Share to Base Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA, Bacterial

Share to DNA, Viral

Share to Gene Expression

Share to Molecular Sequence Data

Share to Saccharomyces cerevisiae

Source

Identifiers

PMID: 8420982

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Site-directed mutagenesis of HIV-1 integrase demonstrates differential effects on integrase functions in vitro.PMID 8420982Read ↗

Mutational scan of the human immunodeficiency virus type 2 integrase protein.Semantic proximity Read ↗

Human immunodeficiency virus type 1 integrase: effect on viral replication of mutations at highly conserved residuesSemantic proximity Read ↗

Genetic analysis of human immunodeficiency virus type 1 integrase and the U3 att site: unusual phenotype of mutants in the zinc finger-like domain.Semantic proximity Read ↗

Sequential Deletion of the Integrase (Gag-Pol) Carboxyl Terminus Reveals Distinct Phenotypic Classes of Defective HIV-1Semantic proximity Read ↗

Human immunodeficiency virus type 1 integrase mutants retain in vitro integrase activity yet fail to integrate viral DNA efficiently during infectionSemantic proximity Read ↗

Human Immunodeficiency Virus Type 1 Integrase Protein Promotes Reverse Transcription through Specific Interactions with the Nucleoprotein Reverse Transcription ComplexSemantic proximity Read ↗

In vivo analysis of retroviral integrase structure and function.Semantic proximity Read ↗

Biochemical and random mutagenesis analysis of the region carrying the catalytic E152 amino acid of HIV-1 integrase.Semantic proximity Read ↗

Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis.Semantic proximity Read ↗

Going beyond Integration: The Emerging Role of HIV-1 Integrase in Virion MorphogenesisSemantic proximity Read ↗

Analysis of mutations in the integration function of Moloney murine leukemia virus: effects on DNA binding and cutting.Semantic proximity Read ↗

Analysis of conserved and non-conserved amino acids critical for ALSV (Avian leukemia and sarcoma viruses) integrase functions in vitro.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.