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Article

Mutational scan of the human immunodeficiency virus type 2 integrase protein.

Journal of virology - 1 May 1998

van den Ent F M, Vos A, Plasterk R H

Abstract excerpt

Retroviral integrase (IN) cleaves linear viral DNA specifically near the ends of the DNA (cleavage reaction) and subsequently couples the processed ends to phosphates in the target DNA (integration reaction). In vitro, IN catalyzes the disintegration reaction, which is the reverse of the integration reaction. Ideally, we would like to test the role of each amino acid in the IN protein. We mutagenized human...

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Identifiers

PMID: 9557677
DOI: 10.1128/JVI.72.5.3916-3924.1998
PMCID: PMC109617

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Source receipt: pubmed, retrieved 7 Sept 2026.

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