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Article

A symmetric region of the HIV-1 integrase dimerization interface is essential for viral replication.

PloS one - 1 Jan 2012

Serrao Erik, Thys Wannes, Demeulemeester Jonas, Al-Mawsawi Laith Q, Christ Frauke, Debyser Zeger, Neamati Nouri

Abstract excerpt

HIV-1 integrase (IN) is an important target for contemporary antiretroviral drug design research. Historically, efforts at inactivating the enzyme have focused upon blocking its active site. However, it has become apparent that new classes of allosteric inhibitors will be necessary to advance the antiretroviral field in light of the emergence of viral strains resistant to contemporary clinically used IN drugs. In...

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Share to Allosteric Regulation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23028829
DOI: 10.1371/journal.pone.0045177
PMCID: PMC3445459

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