Article
Expression of the Ciona intestinalis alternative oxidase (AOX) in Drosophila complements defects in mitochondrial oxidative phosphorylation.
Cell metabolism - 1 May 2009
Fernandez-Ayala Daniel J M, Sanz Alberto, Vartiainen Suvi, Kemppainen Kia K, Babusiak Marek, Mustalahti Eero, Costa Rodolfo, Tuomela Tea, Zeviani Massimo, Chung Jongkyeong, O'Dell Kevin M C, Rustin Pierre, Jacobs Howard T
Abstract excerpt
Defects in mitochondrial OXPHOS are associated with diverse and mostly intractable human disorders. The single-subunit alternative oxidase (AOX) found in many eukaryotes, but not in arthropods or vertebrates, offers a potential bypass of the OXPHOS cytochrome chain under conditions of pathological OXPHOS inhibition. We have engineered Ciona intestinalis AOX for conditional expression in Drosophila melanogaster....
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