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Article

Expression of alternative oxidase in Drosophila ameliorates diverse phenotypes due to cytochrome oxidase deficiency.

Human molecular genetics - 15 Apr 2014

Kemppainen Kia K, Rinne Juho, Sriram Ashwin, Lakanmaa Matti, Zeb Akbar, Tuomela Tea, Popplestone Anna, Singh Satpal, Sanz Alberto, Rustin Pierre, Jacobs Howard T

Abstract excerpt

Mitochondrial dysfunction is a significant factor in human disease, ranging from systemic disorders of childhood to cardiomyopathy, ischaemia and neurodegeneration. Cytochrome oxidase, the terminal enzyme of the mitochondrial respiratory chain, is a frequent target. Lower eukaryotes possess alternative respiratory-chain enzymes that provide non-proton-translocating bypasses for respiratory complexes I...

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Identifiers

PMID: 24293544
DOI: 10.1093/hmg/ddt601
PMCID: PMC3959817

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Expression of alternative oxidase in Drosophila ameliorates diverse phenotypes due to cytochrome oxidase deficiency.PMID 24293544Read ↗

Expression of the Ciona intestinalis alternative oxidase (AOX) in Drosophila complements defects in mitochondrial oxidative phosphorylation.Semantic proximity Read ↗

Expression of yeast NDI1 rescues a Drosophila complex I assembly defect.Semantic proximity Read ↗

Systemic impact of the expression of the mitochondrial alternative oxidase on <i>Drosophila</i> developmentSemantic proximity Read ↗

Developmental arrest in Drosophila melanogaster caused by mitochondrial DNA replication defects cannot be rescued by the alternative oxidase.Semantic proximity Read ↗

The alternative oxidase AOX does not rescue the phenotype of tko25t mutant flies.Semantic proximity Read ↗

Diiron centre mutations in Ciona intestinalis alternative oxidase abolish enzymatic activity and prevent rescue of cytochrome oxidase deficiency in flies.Semantic proximity Read ↗

The alternative oxidase reconfigures the larval mitochondrial electron transport system to accelerate growth and development in <i>Drosophila melanogaster</i>Semantic proximity Read ↗

Alternative oxidase rescues mitochondria-mediated dopaminergic cell loss in DrosophilaSemantic proximity Read ↗

Expression of Ndi1p, an alternative NADH:ubiquinone oxidoreductase, increases mitochondrial membrane potential in a C. elegans model of mitochondrial disease.Semantic proximity Read ↗

AOX delays the onset of the lethal phenotype in a mouse model of Uqcrh (complex III) disease.Semantic proximity Read ↗

Yeast NDI1 expression prevents the unfolded protein response and reconfigures metabolism to restore neuronal function in mitochondrial complex I deficiencySemantic proximity Read ↗

The yeast complex I equivalent NADH dehydrogenase rescues pink1 mutants.Semantic proximity Read ↗

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