Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Developmental arrest in Drosophila melanogaster caused by mitochondrial DNA replication defects cannot be rescued by the alternative oxidase.

Scientific reports - 18 Jul 2018

Rodrigues Ana Paula C, Camargo André F, Andjelković Ana, Jacobs Howard T, Oliveira Marcos T

Abstract excerpt

The xenotopic expression of the alternative oxidase AOX from the tunicate Ciona intestinalis in diverse models of human disease partially alleviates the phenotypic effects of mitochondrial respiratory chain defects. AOX is a non-proton pumping, mitochondrial inner membrane-bound, single-subunit enzyme that can bypass electron transport through the cytochrome segment, providing an additional site for ubiquinone...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Replication
Share to Drosophila Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electron Transport

Share to Genes, Lethal

Share to Mitochondria

Share to Mitochondrial Diseases

Share to Mitochondrial Proteins

Share to Oxidoreductases

Source

Open in PubMed Open full text

Identifiers

PMID: 30022066
DOI: 10.1038/s41598-018-29150-x
PMCID: PMC6052043

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Developmental arrest in Drosophila melanogaster caused by mitochondrial DNA replication defects cannot be rescued by the alternative oxidase.PMID 30022066Read ↗

The alternative oxidase AOX does not rescue the phenotype of tko25t mutant flies.Semantic proximity Read ↗

Systemic impact of the expression of the mitochondrial alternative oxidase on <i>Drosophila</i> developmentSemantic proximity Read ↗

Expression of the Ciona intestinalis alternative oxidase (AOX) in Drosophila complements defects in mitochondrial oxidative phosphorylation.Semantic proximity Read ↗

Expression of alternative oxidase in Drosophila ameliorates diverse phenotypes due to cytochrome oxidase deficiency.Semantic proximity Read ↗

Diiron centre mutations in Ciona intestinalis alternative oxidase abolish enzymatic activity and prevent rescue of cytochrome oxidase deficiency in flies.Semantic proximity Read ↗

The alternative oxidase reconfigures the larval mitochondrial electron transport system to accelerate growth and development in <i>Drosophila melanogaster</i>Semantic proximity Read ↗

AOX delays the onset of the lethal phenotype in a mouse model of Uqcrh (complex III) disease.Semantic proximity Read ↗

Expression of the alternative oxidase complements cytochrome c oxidase deficiency in human cells.Semantic proximity Read ↗

Phenotypic rescue of a Drosophila model of mitochondrial ANT1 disease.Semantic proximity Read ↗

Quantitative evaluation of the mitochondrial proteomes of Drosophila melanogaster adapted to extreme oxygen conditions.Semantic proximity Read ↗

The OXA2a Insertase of Arabidopsis Is Required for Cytochrome c Maturation.Semantic proximity Read ↗

Ligand-Bound GeneSwitch Causes Developmental Aberrations in Drosophila that Are Alleviated by the Alternative Oxidase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.