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Article

Characterizing fatty acid oxidation genes in Drosophila.

G3 (Bethesda, Md.) - 6 Aug 2025

Geronazzo Juliana, Heimerl Abigail, Lindell Linnea, McCrimmon Skye, Stormer Clara, Horvai Brooke, Johnson Ian P, Peterson Tia M, Zuckerman Jocelyn, Scott Anna I, Course Meredith M

Abstract excerpt

In this study, we leverage the power and tractability of Drosophila genetics to better understand the molecular mechanisms underlying a group of rare genetic diseases known as fatty acid oxidation disorders. We use CRISPR-Cas9 to generate mutations in 6 putative fatty acid oxidation genes in Drosophila, then analyze the phenotypes and acylcarnitine profiles of these flies. We find that while Arc42 and CG4860 are...

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Identifiers

PMID: 40519079
DOI: 10.1093/g3journal/jkaf139
PMCID: PMC12341901

Genes

ACADS
ACADM
ETFB
ETFDH
HADHA

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