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Article

Phenotypic rescue of a Drosophila model of mitochondrial ANT1 disease.

Disease models & mechanisms - 1 Jun 2014

Vartiainen Suvi, Chen Shanjun, George Jack, Tuomela Tea, Luoto Kaisa R, O'Dell Kevin M C, Jacobs Howard T

Abstract excerpt

A point mutation in the Drosophila gene that codes for the major adult isoform of adenine nuclear translocase (ANT) represents a model for human diseases that are associated with ANT insufficiency [stress-sensitive B(1) (sesB(1))]. We characterized the organismal, bioenergetic and molecular phenotype of sesB(1) flies then tested strategies to compensate the mutant phenotype. In addition to developmental delay and...

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Identifiers

PMID: 24812436
DOI: 10.1242/dmm.016527
PMCID: PMC4036471

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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