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Article

The alternative oxidase AOX does not rescue the phenotype of tko25t mutant flies.

G3 (Bethesda, Md.) - 21 Aug 2014

Kemppainen Kia K, Kemppainen Esko, Jacobs Howard T

Abstract excerpt

A point mutation [technical knockout(25t) (tko(25t))] in the Drosophila gene coding for mitoribosomal protein S12 generates a phenotype of developmental delay and bang sensitivity. tko(25t) has been intensively studied as an animal model for human mitochondrial diseases associated with deficiency of mitochondrial protein synthesis and consequent multiple respiratory chain defects. Transgenic expression in...

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Identifiers

PMID: 25147191
DOI: 10.1534/g3.114.013946
PMCID: PMC4199707

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