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Article

Expression of the alternative oxidase complements cytochrome c oxidase deficiency in human cells.

EMBO molecular medicine - 1 Apr 2009

Dassa Emmanuel P, Dufour Eric, Gonçalves Sérgio, Paupe Vincent, Hakkaart Gertjan A J, Jacobs Howard T, Rustin Pierre

Abstract excerpt

Cytochrome c oxidase (COX) deficiency is associated with a wide spectrum of clinical conditions, ranging from early onset devastating encephalomyopathy and cardiomyopathy, to neurological diseases in adulthood and in the elderly. No method of compensating successfully for COX deficiency has been reported so far. In vitro, COX-deficient human cells require additional glucose, pyruvate and uridine for normal growth...

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Source

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Identifiers

PMID: 20049701
DOI: 10.1002/emmm.200900001
PMCID: PMC3378104

Genes

COX10
COX15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of the alternative oxidase complements cytochrome c oxidase deficiency in human cells.PMID 20049701Read ↗

Expression of the Ciona intestinalis alternative oxidase (AOX) in Drosophila complements defects in mitochondrial oxidative phosphorylation.Semantic proximity Read ↗

AOX delays the onset of the lethal phenotype in a mouse model of Uqcrh (complex III) disease.Semantic proximity Read ↗

Expression of alternative oxidase in Drosophila ameliorates diverse phenotypes due to cytochrome oxidase deficiency.Semantic proximity Read ↗

Developmental arrest in Drosophila melanogaster caused by mitochondrial DNA replication defects cannot be rescued by the alternative oxidase.Semantic proximity Read ↗

Systemic impact of the expression of the mitochondrial alternative oxidase on <i>Drosophila</i> developmentSemantic proximity Read ↗

The alternative oxidase AOX does not rescue the phenotype of tko25t mutant flies.Semantic proximity Read ↗

Diiron centre mutations in Ciona intestinalis alternative oxidase abolish enzymatic activity and prevent rescue of cytochrome oxidase deficiency in flies.Semantic proximity Read ↗

Early developmental pathology due to cytochrome c oxidase deficiency is revealed by a new zebrafish model.Semantic proximity Read ↗

Heterologous expression of the Crassostrea gigas (Pacific oyster) alternative oxidase in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

Copper and bezafibrate cooperate to rescue cytochrome c oxidase deficiency in cells of patients with SCO2 mutations.Semantic proximity Read ↗

Copper supplementation restores cytochrome c oxidase assembly defect in a mitochondrial disease model of COA6 deficiency.Semantic proximity Read ↗

Human cytochrome oxidase deficiency.Semantic proximity Read ↗

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