Article

Systemic impact of the expression of the mitochondrial alternative oxidase on <i>Drosophila</i> development

2021-09-24

Abstract excerpt

Despite the beneficial effects of xenotopically expressing the mitochondrial alternative oxidase AOX from Ciona intestinalis in mammalian and insect models, important detrimental outcomes have also been reported, raising concerns regarding its potential deployment as a therapeutic enzyme for human mitochondrial diseases. Because of its non-protonmotive terminal oxidase activity, AOX can bypass the cytochrome segm...

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Literature Corpus work: 57ed7c0c-4f90-5b83-aa88-6f3fb158086e
DOI: 10.1101/2021.09.24.461559

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