Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic determinants of white matter hyperintensities on brain scans: a systematic assessment of 19 candidate gene polymorphisms in 46 studies in 19,000 subjects.

Stroke - 1 Jun 2009

Paternoster Lavinia, Chen Wanting, Sudlow Cathie L M

Abstract excerpt

BACKGROUND AND PURPOSE: White matter hyperintensities (WMH) are highly heritable and associated with small artery ischemic stroke, so they may be a useful trait for studying the genetics of small vessel disease. Many studies have attempted to find associations between polymorphisms in various candidate genes and WMH. We aimed to evaluate the evidence for these associations by performing a systematic review and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apolipoproteins E
Share to Brain
Share to Brain Ischemia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to O(6)-Methylguanine-DNA Methyltransferase

Share to Odds Ratio

Share to Peptidyl-Dipeptidase A

Share to Stroke

Source

Identifiers

PMID: 19407234
DOI: 10.1161/STROKEAHA.108.542050

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic determinants of white matter hyperintensities on brain scans: a systematic assessment of 19 candidate gene polymorphisms in 46 studies in 19,000 subjects.PMID 19407234Read ↗

Candidate-gene analysis of white matter hyperintensities on neuroimaging.Semantic proximity Read ↗

Genome-wide meta-analysis of cerebral white matter hyperintensities in patients with stroke.Semantic proximity Read ↗

Genome-wide association study of MRI markers of cerebral small vessel disease in 42,310 participants.Semantic proximity Read ↗

Multiethnic Genome-Wide Association Study of Cerebral White Matter Hyperintensities on MRISemantic proximity Read ↗

The Genetics of White Matter LesionsSemantic proximity Read ↗

Common genetic variation indicates separate etiologies for periventricular and deep white matter hyperintensitiesSemantic proximity Read ↗

Genetic Associations With White Matter Hyperintensities Confer Risk of Lacunar Stroke.Semantic proximity Read ↗

Genetic architecture of white matter hyperintensities differs in hypertensive and nonhypertensive ischemic stroke.Semantic proximity Read ↗

Genetic association studies in stroke: methodological issues and proposed standard criteria.Semantic proximity Read ↗

Genetic determinants of circulating metabolites and the risk of stroke and its subtypes.Semantic proximity Read ↗

Volume of white matter hyperintensities in healthy adults: contribution of age, vascular risk factors, and inflammation-related genetic variants.Semantic proximity Read ↗

Genetic variation in PLEKHG1 is associated with white matter hyperintensities (n = 11,226)Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.