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Article

Genetic determinants of circulating metabolites and the risk of stroke and its subtypes.

European journal of neurology - 1 Dec 2022

Wang Rong-Ze, Huang Shu-Yi, Li Hong-Qi, Yang Yu-Xiang, Chen Shi-Dong, Yu Jin-Tai

Abstract excerpt

BACKGROUND AND PURPOSE: Circulating metabolites have been implicated in stroke pathogenesis, but their genetic determinants are understudied. Using a Mendelian randomization approach, our aim was to provide evidence for the relationship of circulating metabolites and the risk of stroke and its subtypes. METHODS: Genetic instruments of 102 circulating metabolites were obtained from a genome-wide association study,...

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PMID: 36086915
DOI: 10.1111/ene.15549

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