Article

Common genetic variation indicates separate etiologies for periventricular and deep white matter hyperintensities

2019-06-27

Abstract excerpt

We conducted a genome-wide association meta-analysis of two ischemic white matter disease subtypes in the brain, periventricular and deep white matter hyperintensities (PVWMH and DWMH). In 26,654 participants, we found 10 independent genome-wide significant loci only associated with PVWMH, four of which have not been described previously for total WMH burden (16q24.2, 17q21.31, 10q23.1, 7q36.1). Additionally, in b...

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Literature Corpus work: d000e0a1-6a22-5217-a801-7e45bf3a4bca
DOI: 10.1101/683367

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