Article
Genetic architecture of white matter hyperintensities differs in hypertensive and nonhypertensive ischemic stroke.
Stroke - 1 Feb 2015
Adib-Samii Poneh, Devan William, Traylor Matthew, Lanfranconi Silvia, Zhang Cathy R, Cloonan Lisa, Falcone Guido J, Radmanesh Farid, Fitzpatrick Kaitlin, Kanakis Allison, Rothwell Peter M, Sudlow Cathie, Boncoraglio Giorgio B, Meschia James F, Levi Chris, Dichgans Martin, Bevan Steve, Rosand Jonathan, Rost Natalia S, Markus Hugh S
Abstract excerpt
BACKGROUND AND PURPOSE: Epidemiological studies suggest that white matter hyperintensities (WMH) are extremely heritable, but the underlying genetic variants are largely unknown. Pathophysiological heterogeneity is known to reduce the power of genome-wide association studies (GWAS). Hypertensive and nonhypertensive individuals with WMH might have different underlying pathologies. We used GWAS data to calculate...
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