Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Candidate-gene analysis of white matter hyperintensities on neuroimaging.

Journal of neurology, neurosurgery, and psychiatry - 1 Mar 2016

Tran Theresa, Cotlarciuc Ioana, Yadav Sunaina, Hasan Nazeeha, Bentley Paul, Levi Christopher, Worrall Bradford B, Meschia James F, Rost Natalia, Sharma Pankaj

Abstract excerpt

BACKGROUND: White matter hyperintensities (WMH) are a common radiographic finding and may be a useful endophenotype for small vessel diseases. Given high heritability of WMH, we hypothesised that certain genotypes may predispose individuals to these lesions and consequently, to an increased risk of stroke, dementia and death. We performed a meta-analysis of studies investigating candidate genes and WMH to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytochrome P-450 CYP11B2
Share to Databases, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Magnetic Resonance Imaging

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Neuroimaging

Share to Protective Factors

Share to Radiography

Share to White Matter

Source

Open in PubMed Open full text

Identifiers

PMID: 25835038
DOI: 10.1136/jnnp-2014-309685
PMCID: PMC4789815

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Candidate-gene analysis of white matter hyperintensities on neuroimaging.PMID 25835038Read ↗

Genetic determinants of white matter hyperintensities on brain scans: a systematic assessment of 19 candidate gene polymorphisms in 46 studies in 19,000 subjects.Semantic proximity Read ↗

The Genetics of White Matter LesionsSemantic proximity Read ↗

Genome-wide meta-analysis of cerebral white matter hyperintensities in patients with stroke.Semantic proximity Read ↗

Multiethnic Genome-Wide Association Study of Cerebral White Matter Hyperintensities on MRISemantic proximity Read ↗

Genetic Interplay Between White Matter Hyperintensities and Alzheimer’s Disease: A Brain-Body PerspectiveSemantic proximity Read ↗

Genes from a translational analysis support a multifactorial nature of white matter hyperintensities.Semantic proximity Read ↗

Genome-wide association study of MRI markers of cerebral small vessel disease in 42,310 participants.Semantic proximity Read ↗

Genetic Associations With White Matter Hyperintensities Confer Risk of Lacunar Stroke.Semantic proximity Read ↗

Genetic architecture of white matter hyperintensities differs in hypertensive and nonhypertensive ischemic stroke.Semantic proximity Read ↗

Genetic risk factors underlying white matter hyperintensities and cortical atrophy.Semantic proximity Read ↗

Cerebral small vessel disease genomics and its implications across the lifespanSemantic proximity Read ↗

Volume of white matter hyperintensities in healthy adults: contribution of age, vascular risk factors, and inflammation-related genetic variants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.