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Article

Genetic variation in PLEKHG1 is associated with white matter hyperintensities (n = 11,226)

19 Jan 2019

Abstract excerpt

Objective To identify novel genetic associations with white matter hyperintensities (WMH). Methods We performed a genome-wide association meta-analysis of WMH volumes in 11,226 individuals, including 8,429 population-based individuals from UK Biobank and 2,797 stroke patients. Replication of novel loci was performed in an independent dataset of 1,202 individuals. In all studies, WMH were quantified using...

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PMID: 30659137
DOI: 10.1212/wnl.0000000000006952

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