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Article

Genetic Associations With White Matter Hyperintensities Confer Risk of Lacunar Stroke.

Stroke - 1 May 2016

Traylor Matthew, Rutten-Jacobs Loes C A, Thijs Vincent, Holliday Elizabeth G, Levi Chris, Bevan Steve, Malik Rainer, Boncoraglio Giorgio, Sudlow Cathie, Rothwell Peter M, Dichgans Martin, Markus Hugh S

Abstract excerpt

BACKGROUND AND PURPOSE: White matter hyperintensities (WMH) are increased in patients with lacunar stroke. Whether this is because of shared pathogenesis remains unknown. Using genetic data, we evaluated whether WMH-associated genetic susceptibility factors confer risk of lacunar stroke, and therefore whether they share pathogenesis. METHODS: We used a genetic risk score approach to test whether single nucleotide...

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Identifiers

PMID: 27073246
DOI: 10.1161/STROKEAHA.115.011625
PMCID: PMC4839546

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