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Article

Volume of white matter hyperintensities in healthy adults: contribution of age, vascular risk factors, and inflammation-related genetic variants.

Biochimica et biophysica acta - 1 Mar 2012

Raz Naftali, Yang Yiqin, Dahle Cheryl L, Land Susan

Abstract excerpt

Aging is associated with appearance of white matter hyperintensities (WMH) on MRI scans. Vascular risk and inflammation, which increase with age, may contribute to white matter deterioration and proliferation of WMH. We investigated whether circulating biomarkers and genetic variants associated with elevated vascular risk and inflammation are associated with WMH volume in healthy adults (144 volunteers, 44-77...

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Identifiers

PMID: 21889590
DOI: 10.1016/j.bbadis.2011.08.007
PMCID: PMC3245802

Genes

CRP
ACE
APOE
MTHFR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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