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Article

Macrophages of multiple sclerosis patients display deficient SHP-1 expression and enhanced inflammatory phenotype.

Laboratory investigation; a journal of technical methods and pathology - 1 Jul 2009

Christophi George P, Panos Michael, Hudson Chad A, Christophi Rebecca L, Gruber Ross C, Mersich Akos T, Blystone Scott D, Jubelt Burk, Massa Paul T

Abstract excerpt

Recent studies in mice have demonstrated that the protein tyrosine phosphatase SHP-1 is a crucial negative regulator of proinflammatory cytokine signaling, TLR signaling, and inflammatory gene expression. Furthermore, mice genetically lacking SHP-1 (me/me) display a profound susceptibility to inflammatory CNS demyelination relative to wild-type mice. In particular, SHP-1 deficiency may act predominantly in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Protein Tyrosine Phosphatase, Non-Receptor Type 6

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Source

Open in PubMed Open full text

Identifiers

PMID: 19398961
DOI: 10.1038/labinvest.2009.32
PMCID: PMC2725397

Genes

STAT1
STAT6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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