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Article

Multiple sclerosis is linked to MAPKERK overactivity in microglia.

Journal of molecular medicine (Berlin, Germany) - 1 Aug 2021

Ten Bosch George J A, Bolk Jolande, 't Hart Bert A, Laman Jon D

Abstract excerpt

Reassessment of published observations in patients with multiple sclerosis (MS) suggests a microglial malfunction due to inappropriate (over)activity of the mitogen-activated protein kinase pathway ERK (MAPKERK). These observations regard biochemistry as well as epigenetics, and all indicate involvement of this pathway. Recent preclinical research on neurodegeneration already pointed towards a role of MAPK...

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Identifiers

PMID: 33948692
DOI: 10.1007/s00109-021-02080-4
PMCID: PMC8313465

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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