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Article

SENP1 regulates IFN-γ-STAT1 signaling through STAT3-SOCS3 negative feedback loop.

Journal of molecular cell biology - 1 Apr 2017

Yu Tingting, Zuo Yong, Cai Rong, Huang Xian, Wu Shuai, Zhang Chenxi, Chin Y Eugene, Li Dongdong, Zhang Zhenning, Xia Nansong, Wang Qi, Shen Hao, Yao Xuebiao, Zhang Zhong-Yin, Xue Song, Shen Lei, Cheng Jinke

Abstract excerpt

Interferon-γ (IFN-γ) triggers macrophage for inflammation response by activating the intracellular JAK-STAT1 signaling. Suppressor of cytokine signaling 1 (SOCS1) and protein tyrosine phosphatases can negatively modulate IFN-γ signaling. Here, we identify a novel negative feedback loop mediated by STAT3-SOCS3, which is tightly controlled by SENP1 via de-SUMOylation of protein tyrosine phosphatase 1B (PTP1B), in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Tyrosine Phosphatase, Non-Receptor Type 1

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Share to Suppressor of Cytokine Signaling 3 Protein

Source

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Identifiers

PMID: 27702761
DOI: 10.1093/jmcb/mjw042
PMCID: PMC7104919

Genes

SENP1
STAT3
STAT1
SOCS3
SOCS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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