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Article

Motheaten (me/me) mice deficient in SHP-1 are less susceptible to focal cerebral ischemia.

Journal of neuroscience research - 15 May 2006

Beamer Celine A, Brooks Diane M, Lurie Diana I

Abstract excerpt

We have demonstrated previously that the protein tyrosine phosphatase SHP-1 seems to play a role in glial development and is upregulated in non-dividing astrocytes after injury. The present study examines the effect of loss of SHP-1 on the CNS response to permanent focal ischemia. SHP-1 deficient (me/me) mice and wild-type littermates received a permanent middle cerebral artery occlusion (MCAO). At 1, 3, and 7...

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Astrocytes
Brain Ischemia
Cerebral Infarction
Gliosis
Infarction, Middle Cerebral Artery

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Tyrosine Phosphatase, Non-Receptor Type 6

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PMID: 16528752
DOI: 10.1002/jnr.20825

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GFAP

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