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Article

Essential role of MAPK phosphatase-1 in the negative control of innate immune responses.

Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 2006

Salojin Konstantin V, Owusu Iris B, Millerchip Karen A, Potter Mark, Platt Ken A, Oravecz Tamas

Abstract excerpt

TLR-induced innate immunity and inflammation are mediated by signaling cascades leading to activation of the MAPK family of Ser/Thr protein kinases, including p38 MAPK, which controls cytokine release during innate and adoptive immune responses. Failure to terminate such inflammatory reactions may lead to detrimental systemic effects, including septic shock and autoimmunity. In this study, we provide genetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16424221
DOI: 10.4049/jimmunol.176.3.1899

Genes

TLR2
TLR3
TLR4
TLR5
TLR9
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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