Article

Activation of macrophages by lysophosphatidic acid through the lysophosphatidic acid receptor 1 as a novel mechanism in multiple sclerosis pathogenesis

2019-12-11

Abstract excerpt

Multiple sclerosis (MS) is a neuro-inflammatory disease for which the pathogenesis remains largely unclear. Lysophosphatidic acid (LPA) is an endogenous phospholipid that is involved in multiple immune cell functions and is dysregulated in MS. Its receptor LPA 1 is expressed in macrophages and regulates their activation, which is of interest due to the role of macrophage activation in MS in both destruction and r...

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Literature Corpus work: 27dfcb37-2b3c-5233-954e-ec31679101d1
DOI: 10.1101/870980

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