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Article

Activation of Macrophages by Lysophosphatidic Acid through the Lysophosphatidic Acid Receptor 1 as a Novel Mechanism in Multiple Sclerosis Pathogenesis.

Molecular neurobiology - 1 Feb 2021

Fransson Jennifer, Gómez-Conde Ana Isabel, Romero-Imbroda Jesús, Fernández Oscar, Leyva Laura, de Fonseca Fernando Rodríguez, Chun Jerold, Louapre Celine, Van-Evercooren Anne Baron, Zujovic Violetta, Estivill-Torrús Guillermo, García-Díaz Beatriz

Abstract excerpt

Multiple sclerosis (MS) is a neuroinflammatory disease whose pathogenesis remains unclear. Lysophosphatidic acid (LPA) is an endogenous phospholipid involved in multiple immune cell functions and dysregulated in MS. Its receptor LPA1 is expressed in macrophages and regulates their activation, which is of interest due to the role of macrophage activation in MS in both destruction and repair. In this study, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32974731
DOI: 10.1007/s12035-020-02130-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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