Regulation of colony-stimulating factor 1 receptor signaling by the SH2 domain-containing tyrosine phosphatase SHPTP1.

doi:10.1128/MCB.16.7.3685

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Article

Regulation of colony-stimulating factor 1 receptor signaling by the SH2 domain-containing tyrosine phosphatase SHPTP1.

Molecular and cellular biology - 1 Jul 1996

Chen H E, Chang S, Trub T, Neel B G

Abstract excerpt

SHPTP1 (PTP1C, HCP, SHP) is an SH2 domain-containing tyrosine phosphatase expressed predominantly in hematopoietic cells. A frameshift mutation in the SHPTP1 gene causes the motheaten (me/me) mouse. These mice are essentially SHPTP1 null and display multiple hematopoietic abnormalities, most prom...

Topics

Animals
Bone Marrow Cells
Cell Division
Cells, Cultured
Frameshift Mutation
Hematopoietic Stem Cells
Intracellular Signaling Peptides and Proteins
Kinetics
Macrophage Activation
Macrophage Colony-Stimulating Factor
Macrophages

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Inbred C3H

Mice, Knockout

Phenotype

Protein Tyrosine Phosphatase, Non-Receptor Type 11

Protein Tyrosine Phosphatase, Non-Receptor Type 6

Protein Tyrosine Phosphatases

Source

Open in PubMed Open full text

Identifiers

PMID: 8668185
DOI: 10.1128/MCB.16.7.3685
PMCID: PMC231364

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8668185-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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