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Differential expression of SOCS1 in macrophages in relapsing‐remitting and chronic EAE and its role in disease severity

19 Jul 2010

Abstract excerpt

Experimental autoimmune encephalomyelitis (EAE) is a T cell-mediated neuroinflammatory disease that is often used as a model of multiple sclerosis. EAE can follow either relapsing-remitting (RR) or chronic (CH) courses, yet the factors responsible for differentially inducing these forms of disease remain largely unknown. Proinflammatory cytokines play an important role in EAE, and signaling by these cytokines can...

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PMID: 20645407
DOI: 10.1002/glia.21051

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