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Vitamin C alleviates aging defects in a stem cell model for Werner syndrome

6 Jun 2016

Abstract excerpt

Werner syndrome (WS) is a premature aging disorder that mainly affects tissues derived from mesoderm. We have recently developed a novel human WS model using WRN-deficient human mesenchymal stem cells (MSCs). This model recapitulates many phenotypic features of WS. Based on a screen of a number of chemicals, here we found that Vitamin C exerts most efficient rescue for many features in premature aging as shown in...

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PMID: 27271327
DOI: 10.1007/s13238-016-0278-1

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