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Article

MUT-7 Provides Molecular Insight into the Werner Syndrome Exonuclease.

Cells - 8 Dec 2021

Hsu Tsung-Yuan, Hsu Ling-Nung, Chen Shih-Yu, Juang Bi-Tzen

Abstract excerpt

Werner syndrome (WS) is a rare recessive genetic disease characterized by premature aging. Individuals with this disorder develop normally during childhood, but their physiological conditions exacerbate the aging process in late adolescence. WS is caused by mutation of the human WS gene (WRN), which encodes two main domains, a 3'-5' exonuclease and a 3'-5' helicase. Caenorhabditis elegans expresses human WRN...

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Identifiers

PMID: 34943966
DOI: 10.3390/cells10123457
PMCID: PMC8700014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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