Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging

30 Apr 2015

Abstract excerpt

Werner syndrome (WS) is a premature aging disorder caused by WRN protein deficiency. Here, we report on the generation of a human WS model in human embryonic stem cells (ESCs). Differentiation of WRN-null ESCs to mesenchymal stem cells (MSCs) recapitulates features of premature cellular aging, a global loss of H3K9me3, and changes in heterochromatin architecture. We show that WRN associates with heterochromatin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair Mechanisms
Share to Pluripotent Stem Cells Research
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25931448
DOI: 10.1126/science.aaa1356

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human agingPMID 25931448Read ↗

Vitamin C alleviates aging defects in a stem cell model for Werner syndromeSemantic proximity Read ↗

Research on Werner Syndrome: Trends from Past to Present and Future ProspectsSemantic proximity Read ↗

Recent Advances in Understanding Werner SyndromeSemantic proximity Read ↗

Genetic and epigenetic insights into Werner SyndromeSemantic proximity Read ↗

WRN mutations in Werner syndrome.Semantic proximity Read ↗

Reprogramming suppresses premature senescence phenotypes of Werner syndrome cells and maintains chromosomal stability over long-term culture.Semantic proximity Read ↗

WRN at telomeres: implications for aging and cancer.Semantic proximity Read ↗

Werner syndrome protein: functions in the response to DNA damage and replication stress in S-phase.Semantic proximity Read ↗

The Werner syndrome protein affects the expression of genes involved in adipogenesis and inflammation in addition to cell cycle and DNA damage responsesSemantic proximity Read ↗

Werner Syndrome, aging and cancer.Semantic proximity Read ↗

Response to Replication Stress and Maintenance of Genome Stability by WRN, the Werner Syndrome ProteinSemantic proximity Read ↗

Werner syndrome and the function of the Werner protein; what they can teach us about the molecular aging process.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.