Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tumorigenic p53N236S balances aging and tumorigenesis via regulating DREAM/MMB and downstream telomere DNA replication pathways.

Journal of molecular cell biology - 17 Jun 2026

Wang Qianqian, Li Haili, Zheng Quan, Yang Jun, Hou Kailong, Jiang Liangxia, Jia Shuting, Wu Xiaoming, Dan Juhua, Luo Ying

Abstract excerpt

The Werner syndrome (WS) is characterized with both premature aging and tumorigenic phenotypes. In this study, we introduced a tumorigenic mutation p53N236S (referred to as p53S later), which is found in immortalized WS mouse embryo fibroblasts, back into WS mice to investigate its impact on the telomere dysfunction-induced aging process. Intriguingly, the introduction of p53S rescued the aging phenotypes of WS...

Topics

Join the communities discussing this publication.

Aging
Carcinogenesis
DNA Replication
G-Quadruplexes
Telomere

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Suppressor Protein p53

Werner Syndrome

Werner Syndrome Helicase

Source

Open in PubMed Open full text

Identifiers

PMID: 41358820
DOI: 10.1093/jmcb/mjaf053
PMCID: PMC13312281

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tumorigenic p53N236S balances aging and tumorigenesis via regulating DREAM/MMB and downstream telomere DNA replication pathways.PMID 41358820Read ↗

A cascade leading to premature aging phenotypes including abnormal tumor profiles in Werner syndrome (review).Semantic proximity Read ↗

Research on Werner Syndrome: Trends from Past to Present and Future ProspectsSemantic proximity Read ↗

WRN Mutation Update: Mutation Spectrum, Patient Registries, and Translational Prospects.Semantic proximity Read ↗

Werner syndrome helicase modulates G4 DNA-dependent transcription and opposes mechanistically distinct senescence-associated gene expression programsSemantic proximity Read ↗

WRN at telomeres: implications for aging and cancer.Semantic proximity Read ↗

Recent Advances in Understanding Werner SyndromeSemantic proximity Read ↗

Werner syndrome and the function of the Werner protein; what they can teach us about the molecular aging process.Semantic proximity Read ↗

Loss of p21 promoted tumorigenesis in the background of telomere dysfunctions induced by TRF2 and Wrn deficiency.Semantic proximity Read ↗

Werner syndrome protein: functions in the response to DNA damage and replication stress in S-phase.Semantic proximity Read ↗

Downregulation of the <scp>W</scp>erner syndrome protein induces a metabolic shift that compromises redox homeostasis and limits proliferation of cancer cellsSemantic proximity Read ↗

Werner Syndrome, aging and cancer.Semantic proximity Read ↗

Crosstalk among DNA Damage, Mitochondrial Dysfunction, Impaired Mitophagy, Stem Cell Attrition, and Senescence in the Accelerated Ageing Disorder Werner SyndromeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.