Article
Mutations in the WRN gene in mice accelerate mortality in a p53-null background.
Molecular and cellular biology - 1 May 2000
Lombard D B, Beard C, Johnson B, Marciniak R A, Dausman J, Bronson R, Buhlmann J E, Lipman R, Curry R, Sharpe A, Jaenisch R, Guarente L
Abstract excerpt
Werner's syndrome (WS) is a human disease with manifestations resembling premature aging. The gene defective in WS, WRN, encodes a DNA helicase. Here, we describe the generation of mice bearing a mutation that eliminates expression of the C terminus of the helicase domain of the WRN protein. Mutant mice are born at the expected Mendelian frequency and do not show any overt histological signs of accelerated...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.