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Article

Neuropathologic intermediate phenotypes enhance association to Alzheimer susceptibility alleles.

Neurology - 28 Apr 2009

Bennett David A, De Jager Philip L, Leurgans Sue E, Schneider Julie A

Abstract excerpt

OBJECTIVE: The identification of susceptibility alleles to risk of Alzheimer disease (AD) is a major public health priority. Using apolipoprotein E genotype (APOE), we examined whether neuropathologic intermediate phenotypes, the pathology underlying clinical AD that presumably lies intermediate in the causal chain, would increase power for genetic associations. METHODS: More than 700 older persons underwent...

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Identifiers

PMID: 19398704
DOI: 10.1212/WNL.0b013e3181a2e87d
PMCID: PMC2677477

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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