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Article

APOE ε4, Alzheimer's disease pathology, cerebrovascular disease, and cognitive change over the years prior to death.

Psychology and aging - 1 Dec 2013

Yu Lei, Boyle Patricia, Schneider Julie A, Segawa Eisuke, Wilson Robert S, Leurgans Sue, Bennett David A

Abstract excerpt

The goal of this study was to examine the association of the APOE ε4 allele with the late-life cognitive trajectory and test the hypothesis that the association of ε4 with cognitive decline is explained by Alzheimer's disease (AD) neuropathology. Participants (N = 581) came from 2 longitudinal clinical-pathologic studies of aging and dementia, the Religious Orders Study (ROS) and the Memory and Aging Project...

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Identifiers

PMID: 23647000
DOI: 10.1037/a0031642
PMCID: PMC3766432

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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