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Article

Amyloid mediates the association of apolipoprotein E e4 allele to cognitive function in older people.

Journal of neurology, neurosurgery, and psychiatry - 1 Sept 2005

Bennett D A, Schneider J A, Wilson R S, Bienias J L, Berry-Kravis E, Arnold S E

Abstract excerpt

BACKGROUND: The neurobiological changes underlying the association of the apolipoprotein E (APOE) e4 allele with level of cognition are poorly understood. OBJECTIVE: To test the hypothesis that amyloid load can account for (mediate) the association of the APOE e4 allele with level of cognition assessed proximate to death. METHODS: There were 44 subjects with clinically diagnosed Alzheimer's disease and 50 without...

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Source

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Identifiers

PMID: 16107349
DOI: 10.1136/jnnp.2004.054445
PMCID: PMC1739810

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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