Article
Utility of the apolipoprotein E genotype in the diagnosis of Alzheimer's disease. Alzheimer's Disease Centers Consortium on Apolipoprotein E and Alzheimer's Disease.
The New England journal of medicine - 19 Feb 1998
Mayeux R, Saunders A M, Shea S, Mirra S, Evans D, Roses A D, Hyman B T, Crain B, Tang M X, Phelps C H
Abstract excerpt
BACKGROUND: The epsilon4 allele of the gene encoding apolipoprotein E (APOE) is strongly associated with Alzheimer's disease, but its value in the diagnosis remains uncertain. METHODS: We reviewed clinical diagnoses and diagnoses obtained at autopsy in 2188 patients referred to 1 of 26 Alzheimer'...
Topics
- Aged
- Alzheimer Disease
- Apolipoproteins E
- False Positive Reactions
- Female
- Genotype
- Humans
- Male
- ROC Curve
- Sensitivity and Specificity