Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The effect of APOE-epsilon4 on dementia is mediated by Alzheimer neuropathology.

Alzheimer disease and associated disorders - 1 Jan 2000

Mortimer James A, Snowdon David A, Markesbery William R

Abstract excerpt

The degree to which the association of epsilon4 with dementia is mediated by AD lesions in comparison with vascular lesions is controversial. The present study was undertaken to determine the roles of Alzheimer disease (AD) and vascular pathology in mediating the effect of apolipoprotein E (APOE)-epsilon4 alleles on dementia. Clinicopathologic correlations were studied in 267 Catholic sisters participating in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apolipoprotein E4
Share to Cerebral Infarction
Share to Cognition Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intracranial Arteriosclerosis

Share to Neurofibrillary Tangles

Share to Neuropsychological Tests

Share to Plaque, Amyloid

Share to Severity of Illness Index

Source

Open in PubMed Open full text

Identifiers

PMID: 19484916
DOI: 10.1097/wad.0b013e318190a855
PMCID: PMC2752689

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The effect of APOE-epsilon4 on dementia is mediated by Alzheimer neuropathology.PMID 19484916Read ↗

Apolipoprotein E epsilon4 allele, AD pathology, and the clinical expression of Alzheimer's disease.Semantic proximity Read ↗

APOE, vascular pathology, and the AD brain.Semantic proximity Read ↗

Apolipoprotein E epsilon4 allele genotype and the effect of depressive symptoms on the risk of dementia in men: the Honolulu-Asia Aging Study.Semantic proximity Read ↗

Risk estimates of dementia by apolipoprotein E genotypes from a population-based incidence study: the Rotterdam Study.Semantic proximity Read ↗

Apolipoprotein E epsilon4 allele increases risk for psychotic symptoms in Alzheimer's disease.Semantic proximity Read ↗

Neuropathologic intermediate phenotypes enhance association to Alzheimer susceptibility alleles.Semantic proximity Read ↗

APOE genotype influences functional status among elderly without dementia.Semantic proximity Read ↗

Apolipoprotein E epsilon 4, other risk factors, and course of Alzheimer's disease.Semantic proximity Read ↗

The prevalence of apoE-epsilon4 in Alzheimer's disease is age dependent.Semantic proximity Read ↗

Apolipoprotein E epsilon4 association with dementia in a population-based study: The Framingham study.Semantic proximity Read ↗

Apolipoprotein E epsilon4 and incidence of Alzheimer disease in a community population of older persons.Semantic proximity Read ↗

Association of APOE epsilon2/epsilon3/epsilon4 and promoter gene variants with dementia but not cardiovascular mortality in old age.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.