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Article

Age-related changes of neuron numbers in the frontal cortex of a transgenic mouse model of Alzheimer's disease.

Brain structure & function - 1 Sept 2011

Lemmens Marijke A M, Sierksma Annerieke S R, Rutten Bart P F, Dennissen Frank, Steinbusch Harry W M, Lucassen Paul J, Schmitz Christoph

Abstract excerpt

Alzheimer's disease (AD) is a neurodegenerative disorder, characterized by amyloid plaque accumulation, intracellular tangles and neuronal loss in selective brain regions. The frontal cortex, important for executive functioning, is one of the regions that are affected. Here, we investigated the neurodegenerative effects of mutant human amyloid precursor protein (APP) and presenilin 1 (PS1) on frontal cortex...

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Source

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Identifiers

PMID: 21409417
DOI: 10.1007/s00429-011-0305-1
PMCID: PMC3155024

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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