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Article

Age-related changes of neuron numbers in the frontal cortex of a transgenic mouse model of Alzheimer's disease.

Brain structure & function - 1 Sept 2011

Lemmens Marijke A M, Sierksma Annerieke S R, Rutten Bart P F, Dennissen Frank, Steinbusch Harry W M, Lucassen Paul J, Schmitz Christoph

Abstract excerpt

Alzheimer's disease (AD) is a neurodegenerative disorder, characterized by amyloid plaque accumulation, intracellular tangles and neuronal loss in selective brain regions. The frontal cortex, important for executive functioning, is one of the regions that are affected. Here, we investigated the n...

Topics

Age Factors
Alzheimer Disease
Amyloid beta-Protein Precursor
Analysis of Variance
Animals
Frontal Lobe
Gene Knock-In Techniques
Humans
Immunohistochemistry
Mice
Mice, Transgenic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Nerve Degeneration

Neurons

Presenilin-1

Source

Open in PubMed Open full text

Identifiers

PMID: 21409417
DOI: 10.1007/s00429-011-0305-1
PMCID: PMC3155024

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-21409417-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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