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Article

New mouse model of Alzheimer's.

ACS chemical neuroscience - 16 Jul 2014

Nilsson Per, Saito Takashi, Saido Takaomi C

Abstract excerpt

Amyloid β-peptide (Aβ) accumulation is a key characteristic of Alzheimer's disease (AD); therefore, mouse models of AD exhibiting Aβ pathology are valuable tools for unraveling disease mechanisms. However, the overexpression of Aβ precursor protein (APP) used in previous mouse models may cause Aβ-independent artifacts that influence data interpretation. To circumvent these problems, we used an APP knock-in (KI)...

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Source

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Identifiers

PMID: 24852598
DOI: 10.1021/cn500105p
PMCID: PMC4102956

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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