Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model.

doi:10.1016/s0002-9440(10)63388-3

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Article

Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model.

The American journal of pathology - 1 Oct 2004

Casas Caty, Sergeant Nicolas, Itier Jean-Michel, Blanchard Véronique, Wirths Oliver, van der Kolk Nicolien, Vingtdeux Valérie, van de Steeg Evita, Ret Gwenaëlle, Canton Thierry, Drobecq Hervé, Clark Allan, Bonici Bruno, Delacourte André, Benavides Jesús, Schmitz Christoph, Tremp Günter, Bayer Thomas A, Benoit Patrick, Pradier Laurent

Abstract excerpt

Alzheimer's disease (AD) is characterized by a substantial degeneration of pyramidal neurons and the appearance of neuritic plaques and neurofibrillary tangles. Here we present a novel transgenic mouse model, APP(SL)PS1KI that closely mimics the development of AD-related neuropathological features including a significant hippocampal neuronal loss. This transgenic mouse model carries M233T/L235P knocked-in...

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PMID: 15466394
DOI: 10.1016/s0002-9440(10)63388-3
PMCID: PMC1618627

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